The Lewis Group at Imperial College London conducts research in various areas of supramolecular chemistry, including self-assembly, functional mechanically interlocked molecules, and host-guest systems for sensing applications.

Mechanically Interlocked Molecules

Mechanically interlocked molecules, such as rotaxanes and catenanes, are a fascinating class of molecules currently being investigated for a wide variety of applications.

Properties and Emerging Applications of Mechanically Interlocked Ligands
James E. M. Lewis, Marzia Galli and Stephen M. Goldup
Chem. Commun. 2017, 53, 298-312

Iterative Synthesis of Oligo[n]Rotaxanes in Excellent Yield
James E. M. Lewis, Joby Winn, Luca Cera and Stephen M. Goldup
J. Am. Chem. Soc. 2016, 138, 16329

Metallosupramolecular Self-Assembly

Through careful design of ligands and judicious choice of metal ions, complex architectures can be made to self-assemble from the mixing of these components. The resultant metallosupramolecular species can be utilised for a range of applications, including as molecular reaction flasks, drug delivery vehicles, sensors, and for storage of reactive reagents.

Multicavity [PdnL4]2n+ Cages with Controlled Segregated Binding of Different Guests
Dan Preston, James E. M. Lewis and James D. Crowley
J. Am. Chem. Soc. 2017, 139, 2379–2386

Stimuli-responsive Pd2L4 metallosupramolecular cages: towards targeted cisplatin drug delivery
James E. M. Lewis, Emma L. Gavey, Scott A. Cameron and James D. Crowley
Chem. Sci. 2012, 3, 778-784