The Lewis Group at Imperial College London conducts research in various areas of supramolecular chemistry, including self-assembly, functional mechanically interlocked molecules, and host-guest systems for sensing applications.
Mechanically Interlocked Molecules
Mechanically interlocked molecules, such as rotaxanes and catenanes, are a fascinating class of molecules currently being investigated for a wide variety of applications.
Properties and Emerging Applications of Mechanically Interlocked Ligands
James E. M. Lewis, Marzia Galli and Stephen M. Goldup
Chem. Commun. 2017, 53, 298-312
Iterative Synthesis of Oligo[n]Rotaxanes in Excellent Yield
James E. M. Lewis, Joby Winn, Luca Cera and Stephen M. Goldup
J. Am. Chem. Soc. 2016, 138, 16329
Through careful design of ligands and judicious choice of metal ions, complex architectures can be made to self-assemble from the mixing of these components. The resultant metallosupramolecular species can be utilised for a range of applications, including as molecular reaction flasks, drug delivery vehicles, sensors, and for storage of reactive reagents.
Multicavity [PdnL4]2n+ Cages with Controlled Segregated Binding of Different Guests
Dan Preston, James E. M. Lewis and James D. Crowley
J. Am. Chem. Soc. 2017, 139, 2379–2386
Stimuli-responsive Pd2L4 metallosupramolecular cages: towards targeted cisplatin drug delivery
James E. M. Lewis, Emma L. Gavey, Scott A. Cameron and James D. Crowley
Chem. Sci. 2012, 3, 778-784