The Lewis Group at Imperial College London conducts research in various areas of supramolecular chemistry, including self-assembly, functional mechanically interlocked molecules, and host-guest systems for sensing applications. We are located in the new state-of-the-art Molecular Sciences Research Hub at Imperial College’s White City campus.

Mechanically Interlocked Molecules

Mechanically interlocked molecules (MIMs), such as rotaxanes and catenanes, are a fascinating class of molecules currently being investigated for a wide variety of applications. We have an interest in using MIMs as sensors and functional building blocks for metallo-supramolecular constructs.

Properties and Emerging Applications of Mechanically Interlocked Ligands
James E. M. Lewis, Marzia Galli and Stephen M. Goldup
Chem. Commun. 2017, 53, 298-312

Self-templated Synthesis of Amide Catenanes and Formation of a Catenane Coordination Polymer
James E. M. Lewis
Org. Biomol. Chem. 2019, 17, 2442-2447

Metallosupramolecular Self-Assembly

Through careful design of ligands and judicious choice of metal ions, complex architectures can be made to self-assemble from the mixing of these components. The resultant metallosupramolecular species can be utilised for a range of applications, including as molecular reaction flasks, drug delivery vehicles, sensors, and for storage of reactive reagents. In particular we have an interest in developing complex functional ligand frameworks that remain capable of high-fidelity self-assembly.

Metallo-Supramolecular Self-Assembly with Reduced-Symmetry Ligands
James E. M. Lewis and James D. Crowley
ChemPlusChem, 2020, 85, 815-827

Conformational Control of Pd2L4 Assemblies with Unsymmetrical Ligands
James E. M. Lewis, Andrew Tarzia, Andrew J. P. White and Kim E. Jelfs
Chem. Sci. 2020, 11, 677-683