The Lewis Group at the University of Birmingham is a synthetic lab, conducting research in various areas of supramolecular chemistry. We are located within the state-of-the-art Molecular Sciences Building on the Edgbaston Campus. Our particular interests include self-assembly, functional mechanically interlocked molecules, and host-guest systems. Our research spans fundamental molecular design to more application-driven investigations.
Mechanically Interlocked Molecules
Mechanically interlocked molecules (MIMs), such as rotaxanes and catenanes, are a fascinating class of molecules currently being investigated for a wide variety of applications. We have an interest in using MIMs as sensors, in drug delivery, and as functional building blocks for metallo-supramolecular constructs.
Rotaxanes as Cages to Control DNA Binding, Cytotoxicity, and Cellular Uptake of a Small Molecule
Timothy Kench, Peter A. Summers, Marina K. Kuimova, James E. M. Lewis and Ramon Vilar
Angew. Chem. Int. Ed. 2021, 60, 10928-10934
Emerging properties from mechanical tethering within a post-synthetically functionalised catenane scaffold
N. Hoyas Pérez, P. S. Sherin, V. Posligua, J. L. Greenfield, M. J. Fuchter, K. E. Jelfs, M. K. Kuimova and J. E. M. Lewis
Chem. Sci. 2022, 13, 11368-11375
Metallosupramolecular Self-Assembly
Through careful design of ligands and judicious choice of metal ions, complex architectures can be made to self-assemble from the mixing of these components. The resultant metallosupramolecular species can be utilised for a range of applications, including as molecular reaction flasks, drug delivery vehicles, sensors, and for storage of reactive reagents. In particular we have an interest in developing structurally complex, functional ligand frameworks that remain capable of high-fidelity self-assembly. Something we have become especially fascinated by is the orientation-selective incorporation of low-symmetry ligands into coordination cages with the aim of developing cages with anisotropic, information-rich cavities.
Metallo-Supramolecular Self-Assembly with Reduced-Symmetry Ligands
James E. M. Lewis and James D. Crowley
ChemPlusChem, 2020, 85, 815-827
Conformational Control of Pd2L4 Assemblies with Unsymmetrical Ligands
James E. M. Lewis, Andrew Tarzia, Andrew J. P. White and Kim E. Jelfs
Chem. Sci. 2020, 11, 677-683
Pseudo-heterolepticity in Low-Symmetry Metal-Organic Cages
James E. M. Lewis
Angew. Chem. Int. Ed. 2022, 61, e202212392
Diastereoselective self-assembly of low-symmetry PdnL2n nanocages through coordination-sphere engineering
P. Molinska, A. Tarzia, L. Male, K. E. Jelfs and J. E. M. Lewis
Angew. Chem. Int. Ed. 2023, 62, e202315451